Yazar "Kavaklı, İbrahim Halil" için listeleme
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Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
Gül, Şeref; Akyel, Yasemin Kübra; Gül, Zeynep Melis; Işın, Şafak; Özcan, Onur; Korkmaz, Tuba; Selvi, Saba; Danış, İbrahim; Şavluğ İpek, Özgecan; Aygenli, Fatih; Taşkın, Ali Cihan; Akarlar, Büşra Aytül; Özlü, Nurhan; Öztürk, Nuri; Öztürk, Narin; Özer Ünal, Durişehvar; Güzel, Mustafa; Türkay, Metin; Okyar, Alper; Kavaklı, İbrahim Halil (Nature Research, 2022)Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease ... -
Diurnal changes in capecitabine clock-controlled metabolism enzymes are responsible for its pharmacokinetics in male mice
Akyel, Yasemin Kübra; Öztürk Civelek, Dilek; Öztürk Seyhan, Narin; Gül, Şeref; Gazioğlu, Işıl; Pala Kara, Zeliha; Levi, Francis; Kavaklı, İbrahim Halil; Okyar, Alper (SAGE Publications Inc., 2023)The circadian timing system controls absorption, distribution, metabolism, and elimination processes of drug pharmacokinetics over a 24-h period. Exposure of target tissues to the active form of the drug and cytotoxicity ... -
TW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob/ob and high fat-diet-induced obese mice
Sürme, Saliha; Ergün, Çağla; Gül, Şeref; Akyel, Yasemin Kübra; Gül, Zeynep Melis; Özcan, Onur; Şavluğ İpek, Özgecan; Akarlar, Büşra Aytül; Özlü, Nurhan; Taşkın, Ali Cihan; Türkay, Metin; Gören, Ahmet Ceyhan; Barış, İbrahim; Öztürk, Nuri; Güzel, Mustafa; Aydın, Cihan; Okyar, Alper; Kavaklı, İbrahim Halil (Elsevier Inc., 2023)Cryptochromes (CRYs), transcriptional repressors of the circadian clock in mammals, inhibit cAMP production when glucagon activates G-protein coupled receptors. Therefore, molecules that modulate CRYs have the potential ...